Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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    Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

    Tel: +86-543-8128044

    Fax: +86-543-2605568

    Email: info@cydextrin.com

    Add: Boxing Economic Development Zone, Binzhou, Shandong, China

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Hydroxypropyl-β-cyclodextrin: Preparation And Characterization; Effects On Solubility Of Drugs

Conditions for condensation of β-cyclodextrin with propylene oxide were found

 which give preparations of hydroxypropyl-β-cyclodextrin with a narrow 

and symmetrical distribution of the degree of substitution. Furthermore, 

methods for purification of hydroxypropyl-β-cyclodextrins from the

 contaminating oligopropylene glycols were developed. Preparations 

of hydroxypropyl-β-cyclodextrin with low degrees of substitution

 ( < 8) were found to have optimal solubilization properties for drugs and also

 these preparations could be transformed into non-hygroscopic powders; 

the preparations with higher degrees of substitution (1214) were semi-solids of lower solubilization power. The solubilities of 32 drugs in concentrated 

aqueous solutions of hydroxypropyl-β-cyclo-dextrins (4050%) were measured;

 some of these were improved by three orders of magnitude over the corresponding 

solubilities in water.

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Address: Boxing Economic Development Zone, Binzhou, Shandong, China
Tel: +86-0543-8128044
 Fax:+86-543-2605568
 E-mail:info@cydextrin.com
Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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